skeletal muscle ryanodine receptor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:RYR1
gptkbp:binds	gptkb:ATP calcium magnesium ryanodine
gptkbp:category	gptkb:cell_membrane ion channel
gptkbp:dephosphorylatedBy	gptkb:protein_phosphatase_1 gptkb:protein_phosphatase_2A
gptkbp:discoveredBy	gptkb:Andrew_Marks
gptkbp:discoveredIn	1989
gptkbp:expressedIn	skeletal muscle fibers
gptkbp:foundIn	gptkb:skeletal_muscle
gptkbp:function	calcium release channel
gptkbp:gene	gptkb:RYR1_gene
https://www.w3.org/2000/01/rdf-schema#label	skeletal muscle ryanodine receptor
gptkbp:interactsWith	gptkb:calsequestrin gptkb:dihydropyridine_receptor gptkb:junctin gptkb:triadin
gptkbp:involvedIn	excitation-contraction coupling
gptkbp:locatedIn	sarcoplasmic reticulum
gptkbp:locatedOnChromosome	19q13.2
gptkbp:modulatedBy	gptkb:calmodulin gptkb:FKBP12 gptkb:dantrolene caffeine volatile anesthetics halothane
gptkbp:molecularWeight	~2,200 kDa
gptkbp:mutationAssociatedWith	gptkb:central_core_disease nonsense deletion missense duplication malignant hyperthermia
gptkbp:OMIM	180901
gptkbp:orthologIn	brain ryanodine receptor (RYR3) cardiac muscle ryanodine receptor (RYR2)
gptkbp:PDB	gptkb:5TAL 3J8H
gptkbp:phosphorylates	gptkb:protein_kinase_A gptkb:CaMKII
gptkbp:regulates	intracellular calcium concentration
gptkbp:requires	muscle contraction
gptkbp:structure	homotetramer
gptkbp:subunit	gptkb:calcium_release_complex
gptkbp:UniProtID	P21817
gptkbp:bfsParent	gptkb:Ryr1 gptkb:ryanodine_receptor_1
gptkbp:bfsLayer	7