serotonin-norepinephrine reuptake inhibitors

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:class_of_drugs
gptkbp:abbreviation	gptkb:SNRIs
gptkbp:administeredBy	oral route
gptkbp:contraindication	narrow-angle glaucoma uncontrolled hypertension
gptkbp:discoveredIn	1990s
gptkbp:drugClass	antidepressants
gptkbp:example	gptkb:venlafaxine gptkb:desvenlafaxine gptkb:levomilnacipran gptkb:milnacipran gptkb:duloxetine
gptkbp:excretion	kidneys
gptkbp:mechanismOfAction	inhibit reuptake of serotonin and norepinephrine
gptkbp:metabolism	liver
gptkbp:pregnancyCategory	varies by drug
gptkbp:regulates	gptkb:FDA
gptkbp:relatedTo	gptkb:tricyclic_antidepressants gptkb:selective_serotonin_reuptake_inhibitors
gptkbp:riskFactor	gptkb:discontinuation_syndrome gptkb:serotonin_syndrome
gptkbp:sideEffect	nausea dizziness insomnia dry mouth increased blood pressure
gptkbp:usedFor	gptkb:major_depressive_disorder chronic pain anxiety disorders
gptkbp:bfsParent	gptkb:norepinephrine_transporter gptkb:generalized_anxiety_disorder
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	serotonin-norepinephrine reuptake inhibitors