|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
cAMP-dependent phosphorylation
low concentrations of ryanodine
|
|
gptkbp:alternativeName
|
gptkb:RYR2
gptkb:cardiac_muscle_ryanodine_receptor
gptkb:cardiac_ryanodine_receptor
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:arrhythmogenic_right_ventricular_dysplasia
gptkb:catecholaminergic_polymorphic_ventricular_tachycardia
|
|
gptkbp:discoveredBy
|
1990
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000198626
GC01M237282
|
|
gptkbp:expressedIn
|
gptkb:Purkinje_fibers
cardiac muscle
brain (low levels)
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:calcium_channel
mediates calcium release
|
|
gptkbp:gene
|
gptkb:RYR2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ryanodine receptor 2
|
|
gptkbp:inhibitedBy
|
Mg2+
high concentrations of ryanodine
|
|
gptkbp:interactsWith
|
gptkb:calmodulin
gptkb:protein_kinase_A
gptkb:FKBP12.6
|
|
gptkbp:length
|
approximately 791,000 base pairs
|
|
gptkbp:locatedIn
|
sarcoplasmic reticulum
|
|
gptkbp:locatedOnChromosome
|
1q43
|
|
gptkbp:modulatedBy
|
gptkb:dantrolene
caffeine
calcium ions
ryanodine
|
|
gptkbp:molecularWeight
|
565 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:arrhythmia
sudden cardiac death
|
|
gptkbp:numberOfExons
|
105
|
|
gptkbp:OMIM
|
180902
|
|
gptkbp:orthologInMouse
|
gptkb:Ryr2
|
|
gptkbp:PDB
|
6JI8
|
|
gptkbp:phosphorylates
|
gptkb:Ser2030
gptkb:Ser2808
gptkb:Ser2814
|
|
gptkbp:RefSeq
|
gptkb:NM_001035
|
|
gptkbp:subunit
|
homotetramer
|
|
gptkbp:UniProtID
|
gptkb:Q92736
|
|
gptkbp:bfsParent
|
gptkb:RYR2
|
|
gptkbp:bfsLayer
|
7
|