cardiac muscle ryanodine receptor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:activatedBy	calcium caffeine
gptkbp:alsoKnownAs	gptkb:RyR2
gptkbp:discoveredIn	1989
gptkbp:encodedBy	gptkb:RYR2_gene
gptkbp:foundIn	cardiac muscle
gptkbp:function	calcium release channel
gptkbp:gene	gptkb:RYR2
gptkbp:inhibitedBy	ryanodine
gptkbp:interactsWith	gptkb:calmodulin gptkb:protein_kinase_A gptkb:FKBP12.6
gptkbp:involvedIn	excitation-contraction coupling
gptkbp:location	sarcoplasmic reticulum
gptkbp:modulatedBy	phosphorylation oxidation nitrosylation
gptkbp:molecularWeight	~565 kDa
gptkbp:mutationAssociatedWith	gptkb:arrhythmogenic_right_ventricular_dysplasia gptkb:catecholaminergic_polymorphic_ventricular_tachycardia
gptkbp:OMIM	180902
gptkbp:orthologIn	gptkb:brain_ryanodine_receptor_(RyR3) gptkb:skeletal_muscle_ryanodine_receptor_(RyR1)
gptkbp:requires	cardiac muscle contraction
gptkbp:structure	tetramer
gptkbp:UniProtID	gptkb:Q92736
gptkbp:bfsParent	gptkb:RYR2
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	cardiac muscle ryanodine receptor