cardiac muscle ryanodine receptor

URI: https://gptkb.org/entity/cardiac_muscle_ryanodine_receptor
GPTKB entity
Statements (30)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activatedBy calcium
caffeine
gptkbp:alsoKnownAs gptkb:RyR2
gptkbp:discoveredIn 1989
gptkbp:encodedBy gptkb:RYR2_gene
gptkbp:foundIn cardiac muscle
gptkbp:function calcium release channel
gptkbp:gene gptkb:RYR2
https://www.w3.org/2000/01/rdf-schema#label cardiac muscle ryanodine receptor
gptkbp:inhibitedBy ryanodine
gptkbp:interactsWith gptkb:calmodulin
gptkb:protein_kinase_A
gptkb:FKBP12.6
gptkbp:involvedIn excitation-contraction coupling
gptkbp:location sarcoplasmic reticulum
gptkbp:modulatedBy phosphorylation
oxidation
nitrosylation
gptkbp:molecularWeight ~565 kDa
gptkbp:mutationAssociatedWith gptkb:arrhythmogenic_right_ventricular_dysplasia
gptkb:catecholaminergic_polymorphic_ventricular_tachycardia
gptkbp:OMIM 180902
gptkbp:orthologIn gptkb:brain_ryanodine_receptor_(RyR3)
gptkb:skeletal_muscle_ryanodine_receptor_(RyR1)
gptkbp:requires cardiac muscle contraction
gptkbp:structure tetramer
gptkbp:UniProtID gptkb:Q92736
gptkbp:bfsParent gptkb:RYR2
gptkbp:bfsLayer 7