cardiac ryanodine receptor

URI: https://gptkb.org/entity/cardiac_ryanodine_receptor
GPTKB entity
Statements (43)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activatedBy calcium
caffeine
gptkbp:alsoKnownAs gptkb:RyR2
gptkbp:associatedWith gptkb:arrhythmia
heart failure
sudden cardiac death
gptkbp:discoveredIn 1989
gptkbp:encodedBy gptkb:RYR2_gene
gptkbp:foundIn cardiac muscle
gptkbp:function calcium release channel
gptkbp:gene gptkb:RYR2
https://www.w3.org/2000/01/rdf-schema#label cardiac ryanodine receptor
gptkbp:inhibitedBy gptkb:dantrolene
magnesium
ryanodine
gptkbp:interactsWith gptkb:calmodulin
gptkb:protein_kinase_A
gptkb:FKBP12.6
phosphatases
gptkbp:involvedIn excitation-contraction coupling
gptkbp:locatedOnChromosome 1q43
gptkbp:location sarcoplasmic reticulum
gptkbp:modulatedBy phosphorylation
oxidation
nitrosylation
gptkbp:molecularWeight ~565 kDa
gptkbp:mutationAssociatedWith gptkb:arrhythmogenic_right_ventricular_dysplasia
gptkb:catecholaminergic_polymorphic_ventricular_tachycardia
gptkbp:OMIM 180902
gptkbp:PDB gptkb:5GO9
6JI8
gptkbp:relatedTo gptkb:skeletal_ryanodine_receptor
neuronal ryanodine receptor
gptkbp:requires cardiac muscle contraction
gptkbp:species gptkb:human
gptkb:mouse
right
gptkbp:structure homotetramer
gptkbp:subunit gptkb:calcium_release_complex
gptkbp:UniProtID gptkb:Q92736
gptkbp:bfsParent gptkb:RYR2
gptkbp:bfsLayer 7