|
gptkbp:instanceOf
|
nuclear receptor
|
|
gptkbp:activatedBy
|
increases cholesterol efflux
inhibits inflammation
stimulates fatty acid synthesis
|
|
gptkbp:alternativeName
|
gptkb:NR1H3
|
|
gptkbp:associatedWith
|
gptkb:diabetes
gptkb:metabolic_syndrome
atherosclerosis
|
|
gptkbp:dimerizationPartner
|
gptkb:RXR_(Retinoid_X_receptor)
|
|
gptkbp:DNABindingDomain
|
zinc finger
|
|
gptkbp:Entrez_Gene_ID
|
29165
ENSRNOG00000009323
|
|
gptkbp:expressedIn
|
liver
adipose tissue
macrophages
intestine
|
|
gptkbp:fullName
|
gptkb:Liver_X_receptor_alpha
|
|
gptkbp:function
|
regulation of cholesterol, fatty acid, and glucose homeostasis
|
|
gptkbp:gene
|
gptkb:Nr1h3
|
|
gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
rat LXRα
|
|
gptkbp:inhibitedBy
|
decreases cholesterol efflux
reduces lipogenesis
|
|
gptkbp:length
|
447 amino acids
|
|
gptkbp:ligand
|
oxysterols
|
|
gptkbp:ligandBindingDomain
|
present
|
|
gptkbp:locatedOnChromosome
|
chromosome 4q42
|
|
gptkbp:modulatedBy
|
endogenous oxysterols
synthetic agonists (e.g., T0901317)
|
|
gptkbp:molecularWeight
|
50 kDa
|
|
gptkbp:organism
|
gptkb:Rattus_norvegicus
|
|
gptkbp:orthologIn
|
gptkb:mouse_LXRα
human LXRα
human NR1H3
mouse Nr1h3
|
|
gptkbp:pathway
|
lipid metabolism
glucose metabolism
cholesterol homeostasis
|
|
gptkbp:phosphorylates
|
regulates activity
|
|
gptkbp:proteinFamily
|
gptkb:nuclear_hormone_receptor_family
|
|
gptkbp:regulates
|
gptkb:ABCA1_gene
gptkb:CYP7A1_gene
gptkb:SREBP-1c_gene
yes
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:target
|
pharmaceutical research
|
|
gptkbp:UniProtID
|
O35915
|
|
gptkbp:bfsParent
|
gptkb:LXRα
|
|
gptkbp:bfsLayer
|
7
|