|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:fructose_1,6-bisphosphate
|
|
gptkbp:alternativeSplicing
|
gptkb:PKM1_and_PKM2_isoforms
|
|
gptkbp:associatedWith
|
hereditary nonspherocytic hemolytic anemia
|
|
gptkbp:biologicalProcess
|
glycolysis
|
|
gptkbp:cofactor
|
K+
Mg2+
|
|
gptkbp:conserved_domain
|
Pyruvate kinase domain
|
|
gptkbp:enzymeClassification
|
gptkb:EC_2.7.1.40
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
liver
red blood cells
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
eukaryotes
|
|
gptkbp:function
|
catalyzes conversion of phosphoenolpyruvate to pyruvate
|
|
gptkbp:GO_term
|
GO:0004743
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
pyruvate kinase family
|
|
gptkbp:inhibitedBy
|
phenylalanine
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15_(PKM)
gptkb:chromosome_1_(PKLR)
|
|
gptkbp:member
|
gptkb:PKM
gptkb:PKLR
gptkb:PKM1
gptkb:PKM2
gptkb:PKL
PKR
|
|
gptkbp:mutationAssociatedWith
|
gptkb:anemia
pyruvate kinase deficiency
|
|
gptkbp:orthologIn
|
present in yeast
present in animals
present in plants
|
|
gptkbp:pathway
|
glycolysis
gluconeogenesis
|
|
gptkbp:PDB
|
gptkb:1PKN
gptkb:3GR4
4IP7
|
|
gptkbp:product
|
gptkb:ATP
gptkb:pyruvate
|
|
gptkbp:regulates
|
allosteric regulation
ATP inhibition
alanine inhibition
fructose 1,6-bisphosphate activation
|
|
gptkbp:significance
|
gptkb:Warburg_effect
cancer metabolism
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:substrate
|
gptkb:ADP
phosphoenolpyruvate
|
|
gptkbp:bfsParent
|
gptkb:P14618_(human_PKLR)
|
|
gptkbp:bfsLayer
|
7
|