plasminogen activator inhibitor-1 (PAI-1)

URI: https://gptkb.org/entity/plasminogen_activator_inhibitor-1_(PAI-1)
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:protein
serpin
gptkbp:alternativeName gptkb:PAI-1
gptkb:plasminogen_activator_inhibitor_type_1
gptkb:SERPINE1
gptkbp:associatedWith gptkb:cardiovascular_disease
gptkb:metabolic_syndrome
thrombosis
gptkbp:discoveredBy E. G. Astrup
gptkbp:discoveredIn 1978
gptkbp:encodedBy SERPINE1 gene
gptkbp:foundIn gptkb:plasma
adipose tissue
platelets
endothelial cells
gptkbp:halfLife 1-2 hours
https://www.w3.org/2000/01/rdf-schema#label plasminogen activator inhibitor-1 (PAI-1)
gptkbp:inhibitedBy tissue plasminogen activator (tPA)
urokinase (uPA)
gptkbp:locatedOnChromosome 7q22.1
gptkbp:medicalUse biomarker for cardiovascular risk
gptkbp:molecularWeight 45 kDa
gptkbp:OMIM 173360
gptkbp:PDB 1B3K
gptkbp:regulates upregulated by insulin
fibrinolysis
upregulated by inflammatory cytokines
upregulated by glucocorticoids
upregulated by TGF-beta
downregulated by retinoic acid
gptkbp:structure single-chain glycoprotein
gptkbp:UniProtID gptkb:P05121
gptkbp:bfsParent gptkb:EC_3.4.21.26
gptkbp:bfsLayer 7