|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activityDecreasedIn
|
gptkb:liver_disease
malnutrition
pregnancy
organophosphate poisoning
|
|
gptkbp:activityIncreasedIn
|
gptkb:diabetes_mellitus
obesity
nephrotic syndrome
hyperthyroidism
|
|
gptkbp:alsoKnownAs
|
gptkb:pseudocholinesterase
gptkb:butyrylcholinesterase
|
|
gptkbp:assayType
|
gptkb:Ellman_method
|
|
gptkbp:catalyzes
|
hydrolysis of choline esters
|
|
gptkbp:compatibleWith
|
erythrocytes
nerve tissue
|
|
gptkbp:deficiencyCauses
|
prolonged apnea after anesthesia
|
|
gptkbp:EC_number
|
3.1.1.8
|
|
gptkbp:encodedBy
|
gptkb:BCHE_gene
|
|
gptkbp:firstDescribed
|
1932
|
|
gptkbp:foundIn
|
blood plasma
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
plasma cholinesterase
|
|
gptkbp:inhibitedBy
|
gptkb:organophosphates
carbamates
|
|
gptkbp:locatedOnChromosome
|
chromosome 3q26.1-q26.2
|
|
gptkbp:location
|
liver (synthesized)
|
|
gptkbp:molecularWeight
|
340 kDa (tetramer)
|
|
gptkbp:mutationAssociatedWith
|
atypical cholinesterase
dibucaine-resistant cholinesterase
fluoride-resistant cholinesterase
|
|
gptkbp:presentIn
|
many tissues (mainly plasma)
|
|
gptkbp:range
|
3,700–10,400 U/L (varies by lab)
|
|
gptkbp:relatedTo
|
gptkb:acetylcholinesterase
|
|
gptkbp:significance
|
used to assess liver function
used to detect organophosphate poisoning
used to assess risk of prolonged apnea after succinylcholine
|
|
gptkbp:structure
|
tetrameric glycoprotein
|
|
gptkbp:substrate
|
gptkb:procaine
gptkb:succinylcholine
gptkb:butyrylcholine
cocaine
|
|
gptkbp:usedIn
|
forensic toxicology
pharmacogenetics
|
|
gptkbp:usedToMonitor
|
exposure to pesticides
exposure to nerve agents
|
|
gptkbp:bfsParent
|
gptkb:butyrylcholinesterase
|
|
gptkbp:bfsLayer
|
7
|