Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:AChE
gptkb:acetylcholine_hydrolase |
| gptkbp:catalyzes |
hydrolysis of acetylcholine
|
| gptkbp:discoveredBy |
gptkb:Henry_Hallett_Dale
|
| gptkbp:EC_number |
3.1.1.7
|
| gptkbp:expressedIn |
gptkb:skeletal_muscle
erythrocytes brain tissue |
| gptkbp:foundIn |
central nervous system
peripheral nervous system neuromuscular junctions |
| gptkbp:gene |
gptkb:ACHE
|
| https://www.w3.org/2000/01/rdf-schema#label |
acetylcholinesterase
|
| gptkbp:inhibitedBy |
gptkb:donepezil
gptkb:neostigmine gptkb:physostigmine gptkb:rivastigmine gptkb:organophosphates carbamates |
| gptkbp:molecularWeight |
~70 kDa
|
| gptkbp:PDB |
gptkb:1B41
|
| gptkbp:product |
gptkb:choline
acetate |
| gptkbp:role |
terminates synaptic transmission
|
| gptkbp:significance |
target for insecticides
target for Alzheimer's disease drugs target for nerve agents |
| gptkbp:structure |
serine hydrolase
|
| gptkbp:substrate |
gptkb:acetylcholine
|
| gptkbp:UniProtID |
gptkb:P22303
|
| gptkbp:bfsParent |
gptkb:Cholinesterase
|
| gptkbp:bfsLayer |
6
|