Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
|
| gptkbp:compatibleWith |
clinical use (as of 2024)
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:example |
gptkb:SB203580
gptkb:BIRB_796 gptkb:Losmapimod gptkb:VX-702 PH-797804 Pamapimod |
| https://www.w3.org/2000/01/rdf-schema#label |
p38 inhibitors
|
| gptkbp:investigatedBy |
gptkb:COPD
neurodegenerative diseases cardiovascular diseases |
| gptkbp:mechanismOfAction |
inhibit p38 MAPK signaling pathway
|
| gptkbp:sideEffect |
hepatotoxicity
skin rash gastrointestinal disturbances |
| gptkbp:target |
gptkb:p38_MAP_kinase
|
| gptkbp:usedIn |
cancer research
inflammatory diseases rheumatoid arthritis |
| gptkbp:bfsParent |
gptkb:p38_mitogen-activated_protein_kinases
|
| gptkbp:bfsLayer |
7
|