multidrug resistance-associated protein 2

URI: https://gptkb.org/entity/multidrug_resistance-associated_protein_2
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:affects drug toxicity
drug pharmacokinetics
drug efficacy
gptkbp:alsoKnownAs gptkb:ABCC2
gptkb:MRP2
gptkbp:associatedWith gptkb:Dubin-Johnson_syndrome
gptkbp:encodedBy gptkb:ABCC2_gene
gptkbp:Entrez_Gene_ID 1244
gptkbp:expressedIn gptkb:kidney
liver
intestine
gptkbp:foundIn apical membrane of hepatocytes
canalicular membrane
gptkbp:function transports organic anions
involved in drug resistance
gptkbp:hasATPaseActivity true
gptkbp:hasNucleotideBindingDomains 2
gptkbp:hasPolymorphism true
gptkbp:HGNC_ID gptkb:HGNC:54
https://www.w3.org/2000/01/rdf-schema#label multidrug resistance-associated protein 2
gptkbp:humanOrthologOf rat Mrp2
gptkbp:inhibitedBy gptkb:ritonavir
gptkb:probenecid
indomethacin
cyclosporine A
gptkbp:involvedIn detoxification
xenobiotic transport
bile formation
gptkbp:locatedIn gptkb:cell_membrane
gptkbp:locatedOnChromosome gptkb:16q12.1
gptkbp:memberOf gptkb:MRP_subfamily
gptkb:ATP-binding_cassette_transporter_family
gptkbp:molecularWeight ~174 kDa
gptkbp:mutationAssociatedWith gptkb:Dubin-Johnson_syndrome
gptkbp:OMIM 601107
gptkbp:PDB 6BHU
gptkbp:species gptkb:Homo_sapiens
gptkbp:structure transmembrane protein
gptkbp:transmembraneDomains 17
gptkbp:transportation antibiotics
antiviral drugs
anticancer drugs
bile salts
glutathione conjugates
bilirubin glucuronides
gptkbp:UniProtID O15438
gptkbp:bfsParent gptkb:Canalicular_multispecific_organic_anion_transporter
gptkbp:bfsLayer 7