multidrug resistance-associated protein 2

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:affects	drug toxicity drug pharmacokinetics drug efficacy
gptkbp:alsoKnownAs	gptkb:ABCC2 gptkb:MRP2
gptkbp:associatedWith	gptkb:Dubin-Johnson_syndrome
gptkbp:encodedBy	gptkb:ABCC2_gene
gptkbp:Entrez_Gene_ID	1244
gptkbp:expressedIn	gptkb:kidney liver intestine
gptkbp:foundIn	apical membrane of hepatocytes canalicular membrane
gptkbp:function	transports organic anions involved in drug resistance
gptkbp:hasATPaseActivity	true
gptkbp:hasNucleotideBindingDomains	2
gptkbp:hasPolymorphism	true
gptkbp:HGNC_ID	gptkb:HGNC:54
gptkbp:humanOrthologOf	rat Mrp2
gptkbp:inhibitedBy	gptkb:ritonavir gptkb:probenecid indomethacin cyclosporine A
gptkbp:involvedIn	detoxification xenobiotic transport bile formation
gptkbp:locatedIn	gptkb:cell_membrane
gptkbp:locatedOnChromosome	gptkb:16q12.1
gptkbp:memberOf	gptkb:MRP_subfamily gptkb:ATP-binding_cassette_transporter_family
gptkbp:molecularWeight	~174 kDa
gptkbp:mutationAssociatedWith	gptkb:Dubin-Johnson_syndrome
gptkbp:OMIM	601107
gptkbp:PDB	6BHU
gptkbp:species	gptkb:Homo_sapiens
gptkbp:structure	transmembrane protein
gptkbp:transmembraneDomains	17
gptkbp:transportation	antibiotics antiviral drugs anticancer drugs bile salts glutathione conjugates bilirubin glucuronides
gptkbp:UniProtID	O15438
gptkbp:bfsParent	gptkb:Canalicular_multispecific_organic_anion_transporter
gptkbp:bfsLayer	7
http://www.w3.org/2000/01/rdf-schema#label	multidrug resistance-associated protein 2