mitochondrial respiratory chain complex I

URI: https://gptkb.org/entity/mitochondrial_respiratory_chain_complex_I
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alsoKnownAs gptkb:NADH:ubiquinone_oxidoreductase
gptkbp:cofactor gptkb:FMN
iron-sulfur clusters
gptkbp:component electron transport chain
gptkbp:determines cryo-electron microscopy
gptkbp:dysregulationAssociatedWith gptkb:Parkinson's_disease
gptkb:Leigh_syndrome
mitochondrial complex I deficiency
gptkbp:EC_number 1.6.5.3
gptkbp:energyProductionRole ATP synthesis
gptkbp:foundIn eukaryotes
gptkbp:function catalyzes transfer of electrons from NADH to ubiquinone
pumps protons across mitochondrial membrane
gptkbp:geneExample gptkb:NDUFA9
gptkb:ND1
gptkb:NDUFS1
gptkb:NDUFV1
https://www.w3.org/2000/01/rdf-schema#label mitochondrial respiratory chain complex I
gptkbp:inhibitedBy gptkb:piericidin_A
gptkb:rotenone
amytal
gptkbp:locatedIn inner mitochondrial membrane
gptkbp:molecularWeight ~1 MDa
gptkbp:presentIn animals
fungi
plants
gptkbp:step mitochondrial electron transport chain
gptkbp:subunitCount at least 45
gptkbp:subunitOrigin gptkb:mitochondrial_DNA
nuclear DNA
gptkbp:bfsParent gptkb:DB00783
gptkb:DB00170
gptkbp:bfsLayer 6