DB00787

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 1957
gptkbp:ATCCode A10BA02
gptkbp:availableOn gptkb:tablet
oral solution
extended-release tablet
gptkbp:bioavailability 50-60%
gptkbp:brand gptkb:Riomet
gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
gptkbp:CASNumber 657-24-9
gptkbp:contraindication metabolic acidosis
renal impairment
acute or chronic metabolic acidosis
gptkbp:drugClass biguanide
gptkbp:eliminationHalfLife 4-8.7 hours
gptkbp:excretion renal
gptkbp:hasInChIKey gptkb:XZWYZXLIPXDOLR-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C4H11N5
gptkbp:hasSMILES CN(C)C(=N)N=C(N)N
gptkbp:hasUNII 9100L32L2N
https://www.w3.org/2000/01/rdf-schema#label DB00787
gptkbp:indication gptkb:type_2_diabetes_mellitus
gptkb:polycystic_ovary_syndrome_(off-label)
gptkbp:KEGGID D04968
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction decreases hepatic glucose production
increases insulin sensitivity
gptkbp:metabolism not metabolized
gptkbp:molecularWeight 129.164 g/mol
gptkbp:name gptkb:Metformin
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding negligible
gptkbp:PubChem_CID gptkb:DB00787
gptkb:CHEMBL1431
4091
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gastrointestinal upset
lactic acidosis
gptkbp:status approved
gptkbp:synonym gptkb:Glucophage
gptkb:Metformina
gptkb:Metformine
gptkb:Dimethylbiguanide
gptkbp:target gptkb:AMP-activated_protein_kinase
gptkb:mitochondrial_respiratory_chain_complex_I
gptkbp:usedFor gptkb:type_2_diabetes
gptkbp:bfsParent gptkb:acyclovir
gptkbp:bfsLayer 6