DB01050

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 1994
gptkbp:ATCCode A10BA02
gptkbp:bioavailability 50-60%
gptkbp:brand gptkb:Metforal
gptkb:Riomet
gptkb:Siofor
gptkb:Dianben
gptkb:Obimet
gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
gptkbp:CASNumber 657-24-9
gptkbp:contraindication metabolic acidosis
hypersensitivity
renal impairment
gptkbp:drugInteraction gptkb:beer
cimetidine
iodinated contrast agents
gptkbp:eliminationHalfLife 4-8.7 hours
gptkbp:excretion renal
gptkbp:hasInChIKey gptkb:XZWYZXLIPXDOLR-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C4H11N5
gptkbp:hasSMILES CN(C)C(=N)N=C(N)N
https://www.w3.org/2000/01/rdf-schema#label DB01050
gptkbp:indication gptkb:type_2_diabetes_mellitus
gptkb:polycystic_ovary_syndrome_(off-label)
gptkbp:isApprovedDrug true
gptkbp:isGenericDrug true
gptkbp:isNotControlledSubstance true
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction decreases hepatic glucose production
increases insulin sensitivity
gptkbp:metabolism not metabolized
gptkbp:molecularWeight 129.164
gptkbp:name gptkb:Metformin
gptkbp:originatedIn biguanide class
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding negligible
gptkbp:PubChem_CID gptkb:DB01050
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
diarrhea
gastrointestinal upset
lactic acidosis
gptkbp:synonym 1,1-dimethylbiguanide
dimethylbiguanide
gptkbp:target gptkb:AMP-activated_protein_kinase
gptkb:mitochondrial_respiratory_chain_complex_I
gptkbp:bfsParent gptkb:dimethyl_sulfoxide
gptkbp:bfsLayer 6