NADH:ubiquinone oxidoreductase

URI: https://gptkb.org/entity/NADH:ubiquinone_oxidoreductase
GPTKB entity
Statements (29)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alsoKnownAs gptkb:Complex_I
gptkbp:cofactor gptkb:FMN
iron-sulfur clusters
gptkbp:component electron transport chain
gptkbp:determines cryo-electron microscopy
gptkbp:EC_number 1.6.5.3
gptkbp:foundIn eukaryotes
some bacteria
gptkbp:function catalyzes transfer of electrons from NADH to ubiquinone
gptkbp:gene gptkb:mitochondrial_DNA
nuclear DNA
https://www.w3.org/2000/01/rdf-schema#label NADH:ubiquinone oxidoreductase
gptkbp:inhibitedBy gptkb:piericidin_A
gptkb:rotenone
amytal
gptkbp:location inner mitochondrial membrane
gptkbp:molecularWeight ~1 MDa
gptkbp:mutationAssociatedWith gptkb:Leigh_syndrome
mitochondrial diseases
gptkbp:oxidizer gptkb:NADH
gptkbp:pumpsProtons from mitochondrial matrix to intermembrane space
gptkbp:reduces ubiquinone
gptkbp:role ATP synthesis coupling
proton pump
gptkbp:step mitochondrial respiratory chain
gptkbp:subunitCount at least 45
gptkbp:bfsParent gptkb:Mitochondrial_Complex_I_protein
gptkbp:bfsLayer 6