microtubule-associated protein tau

URI: https://gptkb.org/entity/microtubule-associated_protein_tau
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abnormalAggregation gptkb:paired_helical_filaments
gptkbp:alsoKnownAs gptkb:tau_protein
gptkbp:alternativeSplicing exon 10
exon 2
exon 3
gptkbp:associatedWith gptkb:Pick's_disease
gptkb:corticobasal_degeneration
gptkb:progressive_supranuclear_palsy
chronic traumatic encephalopathy
gptkbp:degradedBy autophagy
ubiquitin-proteasome system
gptkbp:depot neurofibrillary tangles in Alzheimer's disease
gptkbp:discoveredBy gptkb:Marc_Kirschner
gptkbp:discoveredIn 1975
gptkbp:encodedBy gptkb:MAPT_gene
gptkbp:expressedIn central nervous system
gptkbp:form neurofibrillary tangles
gptkbp:foundIn gptkb:human
gptkb:mouse
right
gptkbp:function stabilizes microtubules
gptkbp:hasIsoform 6 (in adult human brain)
gptkbp:HGNC_ID 6893
https://www.w3.org/2000/01/rdf-schema#label microtubule-associated protein tau
gptkbp:interactsWith gptkb:GSK3β
gptkb:protein_phosphatase_2A
gptkb:Fyn_kinase
microtubules
gptkbp:involvedIn gptkb:Alzheimer's_disease
gptkb:tauopathies
frontotemporal dementia
gptkbp:length 352-441 amino acids (isoforms)
gptkbp:locatedOnChromosome chromosome 17q21.31
gptkbp:location neurons
axons
gptkbp:molecularWeight 45-65 kDa
gptkbp:mutationAssociatedWith frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17)
gptkbp:OMIM 157140
gptkbp:PDB gptkb:5O3L
gptkbp:phosphorylationSites Ser404
Ser202
Ser396
Thr205
gptkbp:postTranslationalModification phosphorylation
gptkbp:proteinFamily MAP family
gptkbp:regulates microtubule dynamics
gptkbp:structure intrinsically disordered protein
gptkbp:UniProtID P10636
gptkbp:bfsParent gptkb:MAPT
gptkb:Tau_protein
gptkbp:bfsLayer 7