low-density lipoprotein receptor

URI: https://gptkb.org/entity/low-density_lipoprotein_receptor
GPTKB entity
Statements (45)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alternativeName gptkb:LDL_receptor
gptkb:LDLR
gptkbp:associatedWith gptkb:familial_hypercholesterolemia
atherosclerosis
coronary artery disease
gptkbp:binds gptkb:apolipoprotein_B-100
gptkb:apolipoprotein_E
gptkbp:cellularComponent gptkb:endosome
gptkb:plasma_membrane
gptkbp:degradedBy gptkb:lysosome
gptkbp:discoveredBy gptkb:Michael_S._Brown
gptkb:Joseph_L._Goldstein
gptkbp:encodedBy gptkb:LDLR_gene
gptkbp:expressedIn gptkb:adrenal_gland
liver
peripheral tissues
gptkbp:external_link https://www.ncbi.nlm.nih.gov/gene/3949
https://www.uniprot.org/uniprot/P01130
gptkbp:foundIn gptkb:cell_membrane
gptkbp:function mediates endocytosis of cholesterol-rich LDL
gptkbp:GO_term gptkb:GO:0005041
gptkbp:HGNC_ID 6547
https://www.w3.org/2000/01/rdf-schema#label low-density lipoprotein receptor
gptkbp:length 860 amino acids
gptkbp:locatedOnChromosome gptkb:19p13.2
gptkbp:molecularWeight ~120 kDa
gptkbp:mutationAssociatedWith gptkb:familial_hypercholesterolemia
gptkbp:NobelPrizeYear 1985
gptkbp:OMIM 606945
gptkbp:orthologIn mouse Ldlr
rat Ldlr
gptkbp:pathway cholesterol metabolism
lipoprotein uptake
gptkbp:PDB gptkb:1N7D
gptkbp:postTranslationalModification phosphorylation
glycosylation
gptkbp:recycledBy endosomal pathway
gptkbp:regulates regulated by intracellular cholesterol
gptkbp:species gptkb:Homo_sapiens
gptkbp:structure type I transmembrane glycoprotein
gptkbp:UniProtID gptkb:P01130
gptkbp:bfsParent gptkb:LDLR
gptkbp:bfsLayer 7