leucine-rich repeat kinase 2

URI: https://gptkb.org/entity/leucine-rich_repeat_kinase_2
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:LRRK2
gptkbp:alternativeName gptkb:dardarin
gptkbp:associatedWith gptkb:Parkinson's_disease
gptkbp:domain gptkb:COR_domain
gptkb:Roc_domain
kinase domain
WD40 domain
leucine-rich repeat
gptkbp:Entrez_Gene_ID 120892
gptkbp:enzymeCommissionNumber 2.7.11.1
gptkbp:expressedIn gptkb:cancer
gptkb:kidney
brain
gptkbp:function GTPase activity
kinase activity
gptkbp:gene gptkb:LRRK2
gptkbp:HGNC_ID 18618
https://www.w3.org/2000/01/rdf-schema#label leucine-rich repeat kinase 2
gptkbp:inhibitedBy gptkb:MLi-2
gptkb:PF-06447475
GNE-7915
gptkbp:involves autophagy regulation
cytoskeletal dynamics
neuronal signaling
gptkbp:locatedOnChromosome 12
12q12
gptkbp:molecularWeight ~286 kDa
gptkbp:mutationAssociatedWith gptkb:G2019S
gptkb:N1437H
gptkb:sporadic_Parkinson's_disease
gptkb:familial_Parkinson's_disease
I2020T
R1441C
Y1699C
gptkbp:OMIM 609007
gptkbp:orthologInMouse Lrrk2
gptkbp:PDB 6VNO
gptkbp:phosphorylates gptkb:Rab_GTPases
gptkbp:species gptkb:Homo_sapiens
gptkbp:subcellularLocation gptkb:Golgi_apparatus
gptkb:cytoplasm
mitochondria
membrane-associated
gptkbp:UniProtID gptkb:Q5S007
gptkbp:bfsParent gptkb:LRRK2
gptkbp:bfsLayer 7