isocitrate dehydrogenase 1 (IDH1)
GPTKB entity
Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:IDP
gptkb:NADP(+)-specific_isocitrate_dehydrogenase IDH |
| gptkbp:catalyzes |
oxidative decarboxylation of isocitrate to alpha-ketoglutarate
|
| gptkbp:cofactor |
NADP+
|
| gptkbp:EC_number |
1.1.1.42
|
| gptkbp:encodes |
gptkb:isocitrate_dehydrogenase_[NADP]_cytoplasmic
|
| gptkbp:gene |
gptkb:IDH1
|
| gptkbp:HGNC_ID |
HGNC:5382
|
| https://www.w3.org/2000/01/rdf-schema#label |
isocitrate dehydrogenase 1 (IDH1)
|
| gptkbp:involves |
cellular metabolism
citric acid cycle |
| gptkbp:locatedIn |
gptkb:cytoplasm
|
| gptkbp:locatedOnChromosome |
2q34
|
| gptkbp:mutationAssociatedWith |
gptkb:acute_myeloid_leukemia
cholangiocarcinoma glioma R132H |
| gptkbp:OMIM |
147700
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:PDB |
5YVT
|
| gptkbp:product |
gptkb:alpha-ketoglutarate
CO2 NADPH |
| gptkbp:substrate |
gptkb:isocitrate
|
| gptkbp:UniProtID |
O75874
|
| gptkbp:bfsParent |
gptkb:TIBSOVO
|
| gptkbp:bfsLayer |
6
|