isocitrate dehydrogenase [NADP] cytoplasmic
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:IDH1
NADP-dependent isocitrate dehydrogenase cytosolic isocitrate dehydrogenase |
| gptkbp:catalyzes |
oxidative decarboxylation of isocitrate to alpha-ketoglutarate
|
| gptkbp:cofactor |
NADP+
|
| gptkbp:EC_number |
1.1.1.42
|
| gptkbp:function |
tricarboxylic acid cycle
NADPH production |
| gptkbp:gene |
gptkb:IDH1
|
| https://www.w3.org/2000/01/rdf-schema#label |
isocitrate dehydrogenase [NADP] cytoplasmic
|
| gptkbp:location |
gptkb:cytoplasm
|
| gptkbp:mutationAssociatedWith |
gptkb:acute_myeloid_leukemia
glioma |
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:product |
gptkb:alpha-ketoglutarate
CO2 NADPH |
| gptkbp:structure |
homodimer
|
| gptkbp:substrate |
gptkb:isocitrate
|
| gptkbp:UniProtID |
O75874
|
| gptkbp:bfsParent |
gptkb:isocitrate_dehydrogenase_1_(IDH1)
|
| gptkbp:bfsLayer |
7
|