NADP(+)-specific isocitrate dehydrogenase
GPTKB entity
Statements (38)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activatedBy |
gptkb:ADP
Ca2+ |
| gptkbp:alternativeName |
gptkb:IDH1
gptkb:IDH2 isocitrate dehydrogenase (NADP+) |
| gptkbp:CASNumber |
9029-54-5
|
| gptkbp:catalyzes |
oxidative decarboxylation of isocitrate to alpha-ketoglutarate
|
| gptkbp:cofactor |
NADP+
|
| gptkbp:EC_number |
1.1.1.42
|
| gptkbp:foundIn |
mitochondria
cytosol |
| gptkbp:gene |
gptkb:IDH1
gptkb:IDH2 |
| gptkbp:GO_term |
GO:0004450
|
| https://www.w3.org/2000/01/rdf-schema#label |
NADP(+)-specific isocitrate dehydrogenase
|
| gptkbp:inhibitedBy |
gptkb:ATP
NADPH |
| gptkbp:mutationAssociatedWith |
gptkb:cancer
gptkb:acute_myeloid_leukemia glioma |
| gptkbp:participatedIn |
citric acid cycle
glutamate biosynthesis |
| gptkbp:presentIn |
prokaryotes
eukaryotes |
| gptkbp:product |
gptkb:2-oxoglutarate
CO2 NADPH |
| gptkbp:requires |
Mg2+
Mn2+ |
| gptkbp:structure |
homodimer
heterotetramer |
| gptkbp:substrate |
gptkb:H+
gptkb:isocitrate NADP+ |
| gptkbp:UniProtID |
P48735
|
| gptkbp:bfsParent |
gptkb:isocitrate_dehydrogenase_1_(IDH1)
|
| gptkbp:bfsLayer |
7
|