inwardly rectifying potassium channels

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein ion channel
gptkbp:abbreviation	gptkb:Kir_channels
gptkbp:alternativeName	gptkb:IRK_channels gptkb:Kir_channels
gptkbp:discoveredBy	gptkb:Bertil_Hille
gptkbp:encodedBy	gptkb:KCNJ_genes
gptkbp:firstDescribed	1949
gptkbp:foundIn	gptkb:cell_membrane
gptkbp:function	allow potassium ions to flow into cells regulate membrane potential
https://www.w3.org/2000/01/rdf-schema#label	inwardly rectifying potassium channels
gptkbp:importantFor	cardiac muscle neurons pancreatic beta cells
gptkbp:inhibitedBy	barium ions cesium ions
gptkbp:mechanismOfAction	block by Mg2+ block by polyamines voltage-dependent block by intracellular cations
gptkbp:modulatedBy	gptkb:ATP gptkb:G-proteins gptkb:phosphatidylinositol_4,5-bisphosphate_(PIP2)
gptkbp:mutationAssociatedWith	gptkb:Andersen-Tawil_syndrome gptkb:Bartter_syndrome gptkb:congenital_hyperinsulinism long QT syndrome
gptkbp:permeableTo	selective for K+
gptkbp:presentIn	gptkb:Bacteria animals plants eukaryotes
gptkbp:proteinFamily	gptkb:KCNJ
gptkbp:role	insulin secretion resting membrane potential action potential repolarization heart rate regulation
gptkbp:structure	tetrameric
gptkbp:subclassOf	gptkb:potassium_channels
gptkbp:subspecies	gptkb:Kir2.x gptkb:Kir1.x gptkb:Kir3.x gptkb:Kir4.x gptkb:Kir5.x gptkb:Kir6.x gptkb:Kir7.x
gptkbp:transportDirection	inward outward (limited)
gptkbp:bfsParent	gptkb:HGNC:6407
gptkbp:bfsLayer	6