Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
G-proteins (for some subtypes)
|
| gptkbp:alternativeName |
gptkb:Kir_channels
inward rectifier potassium channels |
| gptkbp:blockedIn |
barium ions
cesium ions |
| gptkbp:discoveredBy |
Bertil Hille (research contributions)
|
| gptkbp:encodedBy |
gptkb:KCNJ_genes
|
| gptkbp:firstDescribed |
1980s
|
| gptkbp:foundIn |
gptkb:kidney
brain heart cell membranes |
| gptkbp:fullName |
Inwardly Rectifying Potassium Channels
|
| gptkbp:function |
regulate potassium ion flow across cell membranes
|
| https://www.w3.org/2000/01/rdf-schema#label |
IRK channels
|
| gptkbp:permeableTo |
potassium ions
|
| gptkbp:proteinFamily |
gptkb:KCNJ
|
| gptkbp:regulates |
neuronal excitability
membrane potential cardiac rhythm |
| gptkbp:significance |
mutations can cause Andersen-Tawil syndrome
mutations can cause Bartter syndrome mutations can cause familial atrial fibrillation |
| gptkbp:structure |
tetrameric
|
| gptkbp:subspecies |
Kir1.0
Kir2.0 Kir3.0 Kir4.0 Kir5.0 Kir6.0 Kir7.0 |
| gptkbp:bfsParent |
gptkb:inwardly_rectifying_potassium_channels
|
| gptkbp:bfsLayer |
7
|