Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
ion channel |
| gptkbp:alsoKnownAs |
gptkb:inwardly_rectifying_potassium_channels
|
| gptkbp:discoveredBy |
gptkb:Bertil_Hille
|
| gptkbp:encodedBy |
gptkb:KCNJ_genes
|
| gptkbp:firstDescribed |
1983
|
| gptkbp:foundIn |
cell membranes
|
| gptkbp:function |
allow potassium ions to flow into cells
regulate membrane potential |
| https://www.w3.org/2000/01/rdf-schema#label |
Kir channels
|
| gptkbp:permeableTo |
selective for potassium ions
|
| gptkbp:regulates |
regulated by phosphatidylinositol 4,5-bisphosphate (PIP2)
regulated by ATP regulated by G-proteins regulated by pH |
| gptkbp:significance |
implicated in Andersen-Tawil syndrome
implicated in Bartter syndrome implicated in neonatal diabetes |
| gptkbp:structure |
tetrameric
|
| gptkbp:subfamily |
gptkb:Kir2.x
gptkb:Kir1.x gptkb:Kir3.x gptkb:Kir4.x gptkb:Kir5.x gptkb:Kir6.x gptkb:Kir7.x |
| gptkbp:bfsParent |
gptkb:inwardly_rectifying_potassium_channels
|
| gptkbp:bfsLayer |
7
|