|
gptkbp:instanceOf
|
gptkb:protein
cytokine
|
|
gptkbp:alternativeName
|
gptkb:T_cell_growth_factor
Aldesleukin (recombinant form)
|
|
gptkbp:approvedBy
|
metastatic melanoma
metastatic renal cell carcinoma
|
|
gptkbp:clinicalTrialPhase
|
immunotherapy
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:encodedBy
|
gptkb:IL2_gene
|
|
gptkbp:Entrez_Gene_ID
|
3558
|
|
gptkbp:function
|
stimulates growth of T cells
activates natural killer cells
promotes differentiation of T cells
enhances B cell proliferation
|
|
gptkbp:halfLife
|
7-10 minutes (in plasma)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
interleukin-2 (IL-2)
|
|
gptkbp:length
|
153 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:4q27
|
|
gptkbp:MeSH_ID
|
gptkb:D015850
|
|
gptkbp:molecularWeight
|
15.5 kDa
|
|
gptkbp:OMIM
|
147680
|
|
gptkbp:PDB
|
gptkb:1M47
|
|
gptkbp:producedBy
|
activated T cells
|
|
gptkbp:promotion
|
gptkb:NK_cells
gptkb:B_cells
gptkb:regulatory_T_cells
cytotoxic T lymphocytes
lymphokine-activated killer cells
|
|
gptkbp:recipient
|
gptkb:IL-2_receptor
|
|
gptkbp:regulates
|
immune response
immune tolerance
T cell homeostasis
apoptosis of T cells
clonal expansion of T cells
|
|
gptkbp:sideEffect
|
gptkb:capillary_leak_syndrome
fever
nausea
fatigue
chills
hypotension
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
four alpha-helix bundle
|
|
gptkbp:UniProtID
|
gptkb:P60568
|
|
gptkbp:usedAs
|
immunotherapy
|
|
gptkbp:usedIn
|
HIV research
adoptive cell therapy
autoimmune disease research
transplant rejection research
|
|
gptkbp:bfsParent
|
gptkb:helper_T_cell_(CD4+)
|
|
gptkbp:bfsLayer
|
7
|