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gptkbp:instanceOf
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gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:D-glucose-ATP_phosphotransferase
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gptkbp:CASNumber
|
9001-51-8
|
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gptkbp:catalyzes
|
phosphorylation of glucose
|
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gptkbp:cofactor
|
Mg2+
|
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gptkbp:discoveredBy
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gptkb:Otto_Meyerhof
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gptkbp:discoveredIn
|
1920s
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gptkbp:EC_number
|
2.7.1.1
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gptkbp:expressedIn
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gptkb:skeletal_muscle
brain tissue
liver (mainly glucokinase)
|
|
gptkbp:family
|
transferase
|
|
gptkbp:foundIn
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gptkb:yeast
gptkb:Bacteria
human cells
most living organisms
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gptkbp:gene
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gptkb:HK1
gptkb:HK2
gptkb:HK3
gptkb:HK4
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gptkbp:GO_term
|
gptkb:GO:0004396
|
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gptkbp:hasIsoform
|
gptkb:hexokinase_I
gptkb:hexokinase_II
gptkb:hexokinase_III
gptkb:hexokinase_IV_(glucokinase)
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|
https://www.w3.org/2000/01/rdf-schema#label
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hexokinase
|
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gptkbp:importantFor
|
first step of glycolysis
|
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gptkbp:inhibitedBy
|
gptkb:glucose-6-phosphate
|
|
gptkbp:Km_for_glucose
|
low (high affinity)
|
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gptkbp:location
|
gptkb:cytoplasm
outer mitochondrial membrane
|
|
gptkbp:molecularWeight
|
~100 kDa (varies by isoform)
|
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gptkbp:optimum_pH
|
~37°C (human)
|
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gptkbp:pathway
|
glycolysis
|
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gptkbp:PDB
|
gptkb:1HKB
|
|
gptkbp:pHOptimum
|
~7.5
|
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gptkbp:product
|
gptkb:ADP
gptkb:glucose-6-phosphate
|
|
gptkbp:regulates
|
allosteric inhibition by product
|
|
gptkbp:significance
|
deficiency causes hemolytic anemia
|
|
gptkbp:structure
|
monomeric or dimeric (varies by isoform)
|
|
gptkbp:substrate
|
gptkb:ATP
glucose
|
|
gptkbp:UniProtID
|
P19367 (human HK1)
|
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gptkbp:usedIn
|
biochemical assays
diagnostic tests for glucose
|
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gptkbp:bfsParent
|
gptkb:Warburg_effect
gptkb:enzyme
|
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gptkbp:bfsLayer
|
5
|