|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:insulin
|
|
gptkbp:activity
|
higher in cancer cells
|
|
gptkbp:alternativeName
|
gptkb:HK2
gptkb:hexokinase_type_II
|
|
gptkbp:associatedWith
|
gptkb:Warburg_effect
gptkb:diabetes_mellitus
cancer progression
|
|
gptkbp:catalyzes
|
phosphorylation of glucose to glucose-6-phosphate
|
|
gptkbp:cofactor
|
Mg2+
|
|
gptkbp:discoveredBy
|
gptkb:Otto_Warburg
|
|
gptkbp:EC_number
|
2.7.1.1
|
|
gptkbp:encodedBy
|
gptkb:HK2_gene
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
heart
adipose tissue
cancer cells
|
|
gptkbp:family
|
hexokinase family
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:skeletal_muscle
adipose tissue
|
|
gptkbp:gene
|
gptkb:HK2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
hexokinase II
|
|
gptkbp:inhibitedBy
|
gptkb:glucose-6-phosphate
2-deoxyglucose
lonidamine
|
|
gptkbp:involves
|
energy metabolism
glucose homeostasis
|
|
gptkbp:locale
|
mitochondria-associated
|
|
gptkbp:locatedOnChromosome
|
2p13.3
|
|
gptkbp:molecularWeight
|
about 100 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause metabolic disorders
|
|
gptkbp:number_of_isoforms
|
4 (in humans)
|
|
gptkbp:PDB
|
2NZT
|
|
gptkbp:phosphorylates
|
Serine 617
|
|
gptkbp:product
|
gptkb:ADP
gptkb:glucose-6-phosphate
|
|
gptkbp:regulates
|
upregulated by insulin
downregulated by starvation
|
|
gptkbp:role
|
glycolysis
cancer metabolism
|
|
gptkbp:significance
|
target for cancer therapy
marker for metabolic activity
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:subcellularLocation
|
outer mitochondrial membrane
|
|
gptkbp:substrate
|
gptkb:ATP
glucose
|
|
gptkbp:UniProtID
|
P52789
|
|
gptkbp:bfsParent
|
gptkb:hexokinase
|
|
gptkbp:bfsLayer
|
6
|