|
gptkbp:instanceOf
|
cell surface receptor
lymphocyte
|
|
gptkbp:activatedBy
|
antigen-presenting cell
|
|
gptkbp:develops_from
|
thymocyte
|
|
gptkbp:differentiates_in_response_to
|
cytokine environment
|
|
gptkbp:discoveredBy
|
gptkb:Peter_Doherty
gptkb:Rolf_Zinkernagel
|
|
gptkbp:expressedIn
|
gptkb:CD4_protein
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:foundIn
|
blood
lymphoid tissue
|
|
gptkbp:function
|
activate B cells
activate cytotoxic T cells
activate macrophages
regulate immune response
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
helper T cell (CD4+)
|
|
gptkbp:lifespan
|
weeks to years
|
|
gptkbp:location
|
secondary lymphoid organs
peripheral blood
|
|
gptkbp:marking
|
gptkb:CD4
|
|
gptkbp:produces
|
interleukin-17 (IL-17)
interleukin-4 (IL-4)
interferon-gamma (IFN-γ)
tumor necrosis factor-alpha (TNF-α)
|
|
gptkbp:proliferates_in_response_to
|
gptkb:interleukin-2_(IL-2)
|
|
gptkbp:recognizes_antigen_presented_by
|
MHC class II molecule
|
|
gptkbp:requires
|
cell-mediated immunity
adaptive immunity
antibody production
|
|
gptkbp:role
|
gptkb:HIV/AIDS
autoimmune diseases
immunodeficiency
allergies
|
|
gptkbp:secretes
|
cytokines
|
|
gptkbp:subspecies
|
gptkb:Th17_cell
gptkb:Th1_cell
gptkb:Th2_cell
Tfh cell
regulatory T cell (Treg)
|
|
gptkbp:surface_marker
|
gptkb:CD3
TCR (T cell receptor)
|
|
gptkbp:target
|
gptkb:HIV
|
|
gptkbp:bfsParent
|
gptkb:T-cells
|
|
gptkbp:bfsLayer
|
6
|