heat shock protein HSP 90-beta

URI: https://gptkb.org/entity/heat_shock_protein_HSP_90-beta
GPTKB entity
Statements (43)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:HSP90AB1
gptkbp:encodedBy HSP90AB1 gene
gptkbp:Entrez_Gene_ID 3326
gptkbp:expressedIn most tissues
gptkbp:family gptkb:heat_shock_protein_90_family
gptkbp:function protein folding
cellular stress response
molecular chaperone
stabilization of proteins
https://www.w3.org/2000/01/rdf-schema#label heat shock protein HSP 90-beta
gptkbp:interactsWith gptkb:HSP70
co-chaperones
gptkbp:involvedIn signal transduction
protein degradation
apoptosis regulation
cell cycle control
gptkbp:locatedOnChromosome gptkb:chromosome_6p21
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight ~90 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
gptkbp:PDB 5FWK
gptkbp:postTranslationalModification phosphorylation
ubiquitination
acetylation
gptkbp:RefSeq NP_001017963.2
gptkbp:requires cell viability
gptkbp:significance gptkb:cancer
neurodegenerative diseases
gptkbp:structure homodimer
C-terminal domain
N-terminal domain
ATPase domain
gptkbp:target gptkb:HSP90_inhibitors
gptkbp:UniProtID gptkb:P08238
gptkbp:upregulatedBy heat shock
cellular stress
gptkbp:bfsParent gptkb:6p21.1_(HSP90AB1)
gptkbp:bfsLayer 8