Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alias |
gptkb:CDK2
gptkb:TP2 EST2 hEST2 |
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:cancer
immortalization of cells |
| gptkbp:biologicalProcess |
cell proliferation
telomere maintenance cellular aging regulation reverse transcriptase activity |
| gptkbp:complexWith |
TERC (telomerase RNA component)
|
| gptkbp:discoveredBy |
gptkb:Carol_Greider
gptkb:Elizabeth_Blackburn gptkb:Jack_Szostak |
| gptkbp:encodedBy |
TERT gene
|
| gptkbp:enzymeClassification |
EC 2.7.7.49
|
| gptkbp:expressedIn |
high in stem cells
low in somatic cells |
| gptkbp:fullName |
human telomerase reverse transcriptase
|
| gptkbp:function |
adds telomeric repeats to chromosome ends
catalytic subunit of telomerase |
| gptkbp:gene |
gptkb:TERT
|
| gptkbp:HGNC_ID |
11730
|
| https://www.w3.org/2000/01/rdf-schema#label |
hTERT (human)
|
| gptkbp:interactsWith |
TRF1
TRF2 POT1 TPP1 |
| gptkbp:length |
1132 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:5p15.33
|
| gptkbp:location |
gptkb:nucleus
|
| gptkbp:mutationAssociatedWith |
associated with aplastic anemia
associated with dyskeratosis congenita associated with idiopathic pulmonary fibrosis |
| gptkbp:OMIM |
601686
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:pathway |
cellular senescence
DNA replication telomere extension by telomerase |
| gptkbp:PDB |
6D6V
5CQG |
| gptkbp:postTranslationalModification |
phosphorylation
ubiquitination |
| gptkbp:RefSeq |
NP_937983.2
|
| gptkbp:regulates |
transcriptionally regulated
epigenetically regulated |
| gptkbp:significance |
biomarker for cancer
target for anti-cancer therapy |
| gptkbp:structure |
contains reverse transcriptase motifs
|
| gptkbp:UniProtID |
O14746
|
| gptkbp:bfsParent |
gptkb:Telomerase
|
| gptkbp:bfsLayer |
7
|