|
gptkbp:instanceOf
|
gptkb:medication_class
|
|
gptkbp:approvedBy
|
1950s
|
|
gptkbp:ATCCode
|
C03AA
|
|
gptkbp:cause
|
gout
erectile dysfunction
dyslipidemia
|
|
gptkbp:combines
|
beta blockers
ACE inhibitors
calcium channel blockers
|
|
gptkbp:contraindication
|
sulfa allergy
|
|
gptkbp:discoveredBy
|
gptkb:Merck_&_Co.
|
|
gptkbp:drugClass
|
diuretic
antihypertensive
|
|
gptkbp:effect
|
reduce blood pressure
increase urine output
|
|
gptkbp:example
|
gptkb:hydrochlorothiazide
chlorthalidone
indapamide
metolazone
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:interactsWith
|
gptkb:NSAIDs
gptkb:digoxin
lithium
antidiabetic drugs
|
|
gptkbp:mechanismOfAction
|
inhibit sodium reabsorption in distal convoluted tubule
|
|
gptkbp:metabolism
|
hepatic (varies by agent)
|
|
gptkbp:monitors
|
glucose
blood pressure
uric acid
renal function
serum electrolytes
|
|
gptkbp:notEffectiveAgainst
|
severe renal impairment
|
|
gptkbp:pregnancyCategory
|
C (varies by agent)
|
|
gptkbp:prescribes
|
gptkb:diabetes_insipidus
congestive heart failure
nephrolithiasis (calcium stones)
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:hypercalcemia
hypokalemia
hyponatremia
hyperglycemia
hyperuricemia
|
|
gptkbp:structureContains
|
benzothiadiazine ring
|
|
gptkbp:usedFor
|
edema
hypertension
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Diabetes_Insipidus
gptkb:cholestyramine
gptkb:glibenclamide
gptkb:diabetes_insipidus
gptkb:Chemical_Diabetes_Mellitus
gptkb:Diabetes_Mellitus,_Chemical
gptkb:Glimepiride
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
thiazide diuretics
|