Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
medication class
|
| gptkbp:approvedBy |
1950s
|
| gptkbp:ATCCode |
C03AA
|
| gptkbp:cause |
gout
erectile dysfunction dyslipidemia |
| gptkbp:combines |
beta blockers
ACE inhibitors calcium channel blockers |
| gptkbp:contraindication |
sulfa allergy
|
| gptkbp:discoveredBy |
gptkb:Merck_&_Co.
|
| gptkbp:drugClass |
diuretic
antihypertensive |
| gptkbp:effect |
reduce blood pressure
increase urine output |
| gptkbp:example |
gptkb:hydrochlorothiazide
chlorthalidone indapamide metolazone |
| gptkbp:excretion |
renal
|
| https://www.w3.org/2000/01/rdf-schema#label |
thiazide diuretics
|
| gptkbp:interactsWith |
gptkb:NSAIDs
gptkb:digoxin lithium antidiabetic drugs |
| gptkbp:mechanismOfAction |
inhibit sodium reabsorption in distal convoluted tubule
|
| gptkbp:metabolism |
hepatic (varies by agent)
|
| gptkbp:monitors |
glucose
blood pressure uric acid renal function serum electrolytes |
| gptkbp:notEffectiveAgainst |
severe renal impairment
|
| gptkbp:pregnancyCategory |
C (varies by agent)
|
| gptkbp:prescribes |
gptkb:diabetes_insipidus
congestive heart failure nephrolithiasis (calcium stones) |
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
gptkb:hypercalcemia
hypokalemia hyponatremia hyperglycemia hyperuricemia |
| gptkbp:structureContains |
benzothiadiazine ring
|
| gptkbp:usedFor |
edema
hypertension |
| gptkbp:WHOModelListOfEssentialMedicines |
yes
|
| gptkbp:bfsParent |
gptkb:glyburide
gptkb:diabetes_insipidus |
| gptkbp:bfsLayer |
6
|