|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:ATCCode
|
A10BB
|
|
gptkbp:chemicalClass
|
sulfonylurea derivative
|
|
gptkbp:contraindication
|
gptkb:type_1_diabetes_mellitus
pregnancy
|
|
gptkbp:discoveredBy
|
Marcel Janbon
|
|
gptkbp:drugInteraction
|
gptkb:beer
gptkb:warfarin
gptkb:NSAIDs
|
|
gptkbp:effect
|
lower blood glucose
|
|
gptkbp:example
|
gptkb:glipizide
gptkb:glyburide
gptkb:tolbutamide
gptkb:glibenclamide
gliclazide
chlorpropamide
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Sulfonylureas
|
|
gptkbp:introducedIn
|
1950s
|
|
gptkbp:mechanismOfAction
|
stimulate insulin secretion
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:monitors
|
gptkb:HbA1c
blood glucose
|
|
gptkbp:pregnancyCategory
|
C
|
|
gptkbp:prescriptionStatus
|
prescription only
|
|
gptkbp:riskFactor
|
cardiovascular events
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:hypoglycemia
weight gain
|
|
gptkbp:target
|
pancreatic beta cells
|
|
gptkbp:usedFor
|
gptkb:type_2_diabetes_mellitus
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:A10AB04
|
|
gptkbp:bfsLayer
|
7
|