L-glutamate dehydrogenase

URI: https://gptkb.org/entity/L-glutamate_dehydrogenase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:activatedBy	gptkb:ADP leucine
gptkbp:alternativeName	GLDH L-glutamic acid dehydrogenase glutamic dehydrogenase
gptkbp:associatedWith	gptkb:hyperinsulinism-hyperammonemia_syndrome
gptkbp:biologicalProcess	oxidoreductase activity
gptkbp:CASNumber	9001-46-1
gptkbp:catalyzes	oxidative deamination of L-glutamate to 2-oxoglutarate
gptkbp:cofactor	NADP+ NAD+
gptkbp:EC_number	1.4.1.2
gptkbp:expressedIn	gptkb:kidney brain liver pancreas
gptkbp:foundIn	gptkb:Bacteria animals plants mitochondria
gptkbp:gene	gptkb:GLUD2 gptkb:GLUD1
gptkbp:GO_term	gptkb:GO:0004352
https://www.w3.org/2000/01/rdf-schema#label	L-glutamate dehydrogenase
gptkbp:inhibitedBy	gptkb:ATP gptkb:NADH gptkb:GTP palmitoyl-CoA
gptkbp:optimum_pH	7.8 37°C
gptkbp:pathway	amino acid metabolism nitrogen metabolism TCA cycle
gptkbp:PDB_ID_(human)	1HWZ
gptkbp:product	gptkb:NADH gptkb:2-oxoglutarate ammonia NADPH
gptkbp:proteinFamily	oxidoreductases
gptkbp:reaction_direction	reversible
gptkbp:regulates	allosteric regulation
gptkbp:structure	hexamer
gptkbp:substrate	gptkb:L-glutamate
gptkbp:systematicName	L-glutamate:NAD(P)+ oxidoreductase (deaminating)
gptkbp:UniProtID	P00367
gptkbp:bfsParent	gptkb:glutamate_dehydrogenase gptkb:Glutamate_dehydrogenase
gptkbp:bfsLayer	8