glucose-regulated protein 94

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:GRP94 gptkb:HSP90B1
gptkbp:biologicalProcess	response to stress antigen processing and presentation protein folding in ER
gptkbp:cellularComponent	gptkb:cell_membrane endoplasmic reticulum lumen
gptkbp:downregulatedIn	normal glucose levels
gptkbp:encodedBy	gptkb:HSP90B1_gene
gptkbp:expressedIn	most tissues
gptkbp:family	gptkb:HSP90_family
gptkbp:function	protein folding molecular chaperone quality control of secretory proteins
gptkbp:GOID	GO:0001784 GO:0034976
https://www.w3.org/2000/01/rdf-schema#label	glucose-regulated protein 94
gptkbp:interactsWith	gptkb:integrins gptkb:Toll-like_receptors immunoglobulins
gptkbp:involvedIn	unfolded protein response protein homeostasis ER stress response
gptkbp:locatedIn	gptkb:endoplasmic_reticulum
gptkbp:locatedOnChromosome	gptkb:chromosome_12q23-q24
gptkbp:molecularWeight	94 kDa
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	gptkb:mouse gptkb:yeast right
gptkbp:PDB	gptkb:2O1U
gptkbp:postTranslationalModification	glycosylation
gptkbp:requires	cell survival embryonic development
gptkbp:role	immune response cellular stress response antigen presentation
gptkbp:significance	therapeutic target potential cancer biomarker autoimmune disease involvement
gptkbp:structure	contains C-terminal domain contains N-terminal domain contains ATP-binding domain
gptkbp:UniProtID	P14625
gptkbp:upregulatedBy	heat shock ER stress glucose deprivation
gptkbp:bfsParent	gptkb:GRP94 gptkb:HSP90B1
gptkbp:bfsLayer	8