epithelial sodium channels (ENaC)
GPTKB entity
Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:aldosterone
|
| gptkbp:alternativeName |
gptkb:ENaC
amiloride-sensitive sodium channel |
| gptkbp:encodedBy |
SCNN1A
SCNN1B SCNN1D SCNN1G |
| gptkbp:expressedIn |
colon epithelium
collecting duct distal nephron airway epithelium |
| gptkbp:firstDescribed |
1993
|
| gptkbp:foundIn |
epithelial cells
|
| gptkbp:function |
sodium ion transport
|
| gptkbp:inhibitedBy |
gptkb:triamterene
gptkb:amiloride |
| gptkbp:locatedIn |
gptkb:cancer
gptkb:kidney colon sweat glands |
| gptkbp:locatedOnChromosome |
chromosome 1 (SCNN1D)
chromosome 12 (SCNN1A) chromosome 16 (SCNN1B) chromosome 16 (SCNN1G) |
| gptkbp:memberOf |
ENaC/DEG family
|
| gptkbp:modulatedBy |
proteases
Nedd4-2 serum and glucocorticoid-regulated kinase (SGK1) |
| gptkbp:mutationAssociatedWith |
gptkb:Liddle_syndrome
pseudohypoaldosteronism type 1 |
| gptkbp:permeableTo |
K+
Na+ |
| gptkbp:regulates |
sodium reabsorption
|
| gptkbp:relatedTo |
gptkb:Liddle_syndrome
pseudohypoaldosteronism type 1 |
| gptkbp:requires |
airway surface liquid homeostasis
salt taste perception |
| gptkbp:role |
fluid balance
blood pressure regulation |
| gptkbp:structure |
heterotrimeric
|
| gptkbp:subunit |
gptkb:government_agency
alpha beta gamma |
| gptkbp:target |
diuretics
|
| gptkbp:bfsParent |
gptkb:DEG/ENaC_family
|
| gptkbp:bfsLayer |
8
|
| https://www.w3.org/2000/01/rdf-schema#label |
epithelial sodium channels (ENaC)
|