Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
peptide
vasoactive peptide |
| gptkbp:actsOn |
gptkb:pituitary_gland
gastrointestinal tract neurons fibroblasts adrenal cortex vascular smooth muscle cells kidney tissue liver tissue cardiomyocytes lung tissue glomerular mesangial cells |
| gptkbp:aminoAcidLength |
21
|
| gptkbp:associatedWith |
heart failure
atherosclerosis hypertension chronic kidney disease pulmonary arterial hypertension |
| gptkbp:discoveredBy |
Masashi Yanagisawa
|
| gptkbp:discoveredIn |
1988
|
| gptkbp:encodedBy |
gptkb:EDN1_gene
|
| gptkbp:foundIn |
endothelial cells
|
| gptkbp:function |
cell proliferation
regulation of blood pressure vasoconstriction |
| gptkbp:halfLife |
1-2 minutes
|
| gptkbp:HGNC_ID |
3176
|
| https://www.w3.org/2000/01/rdf-schema#label |
endothelin-1
|
| gptkbp:inhibitedBy |
gptkb:bosentan
nitric oxide atrial natriuretic peptide ambrisentan macitentan prostacyclin |
| gptkbp:locatedOnChromosome |
6p24.1
|
| gptkbp:molecularWeight |
2.5 kDa
|
| gptkbp:predecessor |
preproendothelin-1
|
| gptkbp:promotion |
gptkb:angiotensin_II
gptkb:hypoxia gptkb:thrombin cytokines shear stress |
| gptkbp:recipient |
gptkb:endothelin_receptor_type_A
gptkb:endothelin_receptor_type_B |
| gptkbp:relatedTo |
endothelin-2
endothelin-3 |
| gptkbp:structure |
21-amino acid peptide
|
| gptkbp:UniProtID |
P05305
|
| gptkbp:bfsParent |
gptkb:Weibel-Palade_bodies
|
| gptkbp:bfsLayer |
7
|