|
gptkbp:instanceOf
|
gptkb:peptide
gptkb:vasoactive_peptide
|
|
gptkbp:actsOn
|
gptkb:pituitary_gland
gptkb:neurons
gastrointestinal tract
fibroblasts
adrenal cortex
vascular smooth muscle cells
kidney tissue
liver tissue
cardiomyocytes
lung tissue
glomerular mesangial cells
|
|
gptkbp:aminoAcidLength
|
21
|
|
gptkbp:associatedWith
|
heart failure
atherosclerosis
hypertension
chronic kidney disease
pulmonary arterial hypertension
|
|
gptkbp:discoveredBy
|
Masashi Yanagisawa
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:encodedBy
|
gptkb:EDN1_gene
|
|
gptkbp:foundIn
|
endothelial cells
|
|
gptkbp:function
|
cell proliferation
regulation of blood pressure
vasoconstriction
|
|
gptkbp:halfLife
|
1-2 minutes
|
|
gptkbp:HGNC_ID
|
3176
|
|
gptkbp:inhibitedBy
|
gptkb:bosentan
nitric oxide
atrial natriuretic peptide
ambrisentan
macitentan
prostacyclin
|
|
gptkbp:locatedOnChromosome
|
6p24.1
|
|
gptkbp:molecularWeight
|
2.5 kDa
|
|
gptkbp:predecessor
|
preproendothelin-1
|
|
gptkbp:promotion
|
gptkb:angiotensin_II
gptkb:hypoxia
gptkb:thrombin
cytokines
shear stress
|
|
gptkbp:recipient
|
gptkb:endothelin_receptor_type_A
gptkb:endothelin_receptor_type_B
|
|
gptkbp:relatedTo
|
endothelin-2
endothelin-3
|
|
gptkbp:structure
|
21-amino acid peptide
|
|
gptkbp:UniProtID
|
P05305
|
|
gptkbp:bfsParent
|
gptkb:Weibel-Palade_bodies
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
endothelin-1
|