|
gptkbp:instanceOf
|
gptkb:drug
small molecule
|
|
gptkbp:approvalYear
|
2001
|
|
gptkbp:approvedBy
|
gptkb:FDA
gptkb:EMA
|
|
gptkbp:ATCCode
|
C02KX01
|
|
gptkbp:bindingTarget
|
gptkb:endothelin_receptor_type_A
gptkb:endothelin_receptor_type_B
|
|
gptkbp:brand
|
gptkb:Tracleer
|
|
gptkbp:CASNumber
|
147536-97-8
|
|
gptkbp:contraindication
|
pregnancy
hepatic impairment
|
|
gptkbp:developedBy
|
gptkb:Actelion_Pharmaceuticals
|
|
gptkbp:eliminationHalfLife
|
5 hours
|
|
gptkbp:excretion
|
bile
|
|
gptkbp:hasMolecularFormula
|
C27H29N5O6S
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
bosentan
|
|
gptkbp:KEGGID
|
D00219
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
endothelin receptor antagonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
551.62 g/mol
|
|
gptkbp:pregnancyCategory
|
X
|
|
gptkbp:PubChem_CID
|
CHEMBL1425
104865
DB00559
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:anemia
headache
liver enzyme elevation
|
|
gptkbp:UNII
|
Y43GF64R34
|
|
gptkbp:usedFor
|
pulmonary arterial hypertension
|
|
gptkbp:bfsParent
|
gptkb:Sodium_taurocholate_co-transporting_polypeptide
gptkb:Tracleer
|
|
gptkbp:bfsLayer
|
7
|