|
gptkbp:instance_of
|
gptkb:drug
|
|
gptkbp:bfsLayer
|
5
|
|
gptkbp:bfsParent
|
gptkb:Tracleer
|
|
gptkbp:activities
|
endothelin receptor antagonist
|
|
gptkbp:approves
|
gptkb:2001
gptkb:FDA
|
|
gptkbp:brand
|
gptkb:Tracleer
|
|
gptkbp:class
|
antihypertensive
|
|
gptkbp:clinical_trial
|
Phase III
treatment of pulmonary hypertension
|
|
gptkbp:contraindication
|
gptkb:bosentan
pregnancy
severe liver impairment
|
|
gptkbp:dosage_form
|
gptkb:tablet
|
|
gptkbp:duration
|
long-term
|
|
gptkbp:effective_date
|
gptkb:2001
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:formulation
|
oral tablet
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
bosentan
|
|
gptkbp:indication
|
heart failure
|
|
gptkbp:ingredients
|
gptkb:bosentan
C27 H29 N5 O3 S
|
|
gptkbp:interacts_with
|
gptkb:cyclosporine
gptkb:warfarin
gptkb:glyburide
|
|
gptkbp:is_atype_of
|
C02 K X01
|
|
gptkbp:is_available_on
|
generic drug
|
|
gptkbp:is_monitored_by
|
liver function tests
|
|
gptkbp:is_used_for
|
pulmonary arterial hypertension
|
|
gptkbp:lifespan
|
5 hours
|
|
gptkbp:manager
|
oral
|
|
gptkbp:marketed_as
|
gptkb:Actelion_Pharmaceuticals
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pharmacokinetics
|
vasodilation
oral bioavailability 50%
|
|
gptkbp:safety_features
|
Category X
|
|
gptkbp:side_effect
|
dizziness
fatigue
headache
nausea
nasal congestion
diarrhea
edema
flushing
liver function abnormalities
|
|
gptkbp:type_of
|
157283-68-6
|
|
gptkbp:weight
|
453.61 g/mol
|