endothelin receptor type A

URI: https://gptkb.org/entity/endothelin_receptor_type_A
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:G_protein-coupled_receptor
gptkbp:associatedWith gptkb:cancer
heart failure
kidney disease
pulmonary arterial hypertension
systemic hypertension
gptkbp:binds gptkb:endothelin-1
endothelin-2
endothelin-3
gptkbp:encodedBy EDNRA gene
gptkbp:enemyOf gptkb:bosentan
ambrisentan
macitentan
BQ-123
BQ-788
atrasentan
darusentan
sitaxentan
gptkbp:Entrez_Gene_ID ENSG00000151617
gptkbp:expressedIn gptkb:cancer
gptkb:kidney
gptkb:placenta
heart
liver
vascular smooth muscle cells
gptkbp:family rhodopsin-like receptors
gptkbp:foundIn gptkb:human
gptkb:mouse
right
gptkbp:function cell proliferation
vasoconstriction
gptkbp:HGNC_ID 3171
https://www.w3.org/2000/01/rdf-schema#label endothelin receptor type A
gptkbp:length 427
gptkbp:locatedOn gptkb:cell_membrane
gptkbp:locatedOnChromosome chromosome 4q31.22
gptkbp:MIM_number 131243
gptkbp:molecularWeight 48 kDa
gptkbp:otherName EDNRA
ETA receptor
gptkbp:PDB 5GLH
6IGK
6IGL
gptkbp:RefSeq NM_001957
gptkbp:type Gq/11 protein pathway
phospholipase C activation
gptkbp:UniProtID P25101
gptkbp:bfsParent gptkb:ET-1
gptkbp:bfsLayer 7