|
gptkbp:instanceOf
|
gptkb:antibiotic
tetracycline antibiotic
|
|
gptkbp:approvedBy
|
1967
|
|
gptkbp:ATCCode
|
J01AA01
|
|
gptkbp:brand
|
Declomycin
|
|
gptkbp:CASNumber
|
64-73-3
|
|
gptkbp:chemicalClass
|
gptkb:tetracycline
|
|
gptkbp:color
|
yellow
|
|
gptkbp:contraindication
|
pregnancy
children under 8
|
|
gptkbp:discoveredBy
|
gptkb:Lederle_Laboratories
|
|
gptkbp:drugClass
|
antibacterial
|
|
gptkbp:eliminationHalfLife
|
10-16 hours
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:FDAApproved
|
yes
|
|
gptkbp:hasMolecularFormula
|
C21H21ClN2O8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
demeclocycline
|
|
gptkbp:interactsWith
|
gptkb:warfarin
iron supplements
penicillins
calcium supplements
antacids
oral contraceptives
|
|
gptkbp:KEGGID
|
gptkb:D07810
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits protein synthesis
antagonizes antidiuretic hormone
|
|
gptkbp:meltingPoint
|
220-225°C
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:origin
|
gptkb:Streptomyces_aureofaciens
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:pregnancyRisk
|
teratogenic
|
|
gptkbp:proteinBinding
|
60-80%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1200692
54680676
DB00618
|
|
gptkbp:riskFactor
|
bone growth inhibition in children
tooth discoloration in children
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:nephrogenic_diabetes_insipidus
nausea
vomiting
diarrhea
photosensitivity
|
|
gptkbp:solubility
|
slightly soluble in water
|
|
gptkbp:synonym
|
demeclocycline hydrochloride
|
|
gptkbp:UNII
|
Q7D4AST1PU
|
|
gptkbp:usedFor
|
gptkb:SIADH
bacterial infections
|
|
gptkbp:bfsParent
|
gptkb:Tetracyclines
|
|
gptkbp:bfsLayer
|
5
|