tetracycline

URI: https://gptkb.org/entity/tetracycline

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:chemical_compound gptkb:antibiotic
gptkbp:ATCCode	J01AA07
gptkbp:bioavailability	60–80%
gptkbp:CASNumber	60-54-8
gptkbp:category	gptkb:WHO_essential_medicines gptkb:polyketides antimicrobial agents heterocyclic compounds tetracycline antibiotics
gptkbp:contraindication	pregnancy children under 8 years
gptkbp:discoveredBy	gptkb:Benjamin_Minge_Duggar
gptkbp:discoveredIn	1945
gptkbp:eliminationHalfLife	6–11 hours
gptkbp:excretion	renal biliary
gptkbp:hasMolecularFormula	C22H24N2O8
gptkbp:hasUNII	8Y164V895Y
https://www.w3.org/2000/01/rdf-schema#label	tetracycline
gptkbp:IUPACName	(4S,4aS,5aR,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide
gptkbp:KEGGID	D00008
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	inhibits protein synthesis
gptkbp:meltingPoint	213–215 °C
gptkbp:metabolism	hepatic
gptkbp:origin	gptkb:Streptomyces_aureofaciens
gptkbp:pregnancyCategory	D (US)
gptkbp:proteinBinding	60%
gptkbp:PubChem_CID	54675776 CHEBI:27902 DB00759
gptkbp:routeOfAdministration	oral topical intravenous
gptkbp:sideEffect	photosensitivity gastrointestinal upset tooth discoloration
gptkbp:target	gptkb:bacterial_30S_ribosomal_subunit
gptkbp:usedFor	gptkb:plague cholera malaria brucellosis acne bacterial infections
gptkbp:WHOModelListOfEssentialMedicines	true
gptkbp:bfsParent	gptkb:Gonorrhea gptkb:Syphilis gptkb:Tetracyclines
gptkbp:bfsLayer	5