|
gptkbp:instanceOf
|
antibiotic class
|
|
gptkbp:ATCCode
|
gptkb:J01AA
|
|
gptkbp:chemicalFormula
|
four hydrocarbon rings
|
|
gptkbp:contraindication
|
pregnancy
children under 8
|
|
gptkbp:discoveredIn
|
1940s
|
|
gptkbp:drugInteraction
|
dairy products
iron supplements
antacids
oral contraceptives
|
|
gptkbp:eliminatedIn
|
renal
biliary
|
|
gptkbp:example
|
gptkb:tetracycline
gptkb:demeclocycline
gptkb:minocycline
doxycycline
oxytetracycline
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tetracyclines
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibit protein synthesis
|
|
gptkbp:origin
|
gptkb:Streptomyces_bacteria
natural and semi-synthetic
|
|
gptkbp:pregnancyCategory
|
D
|
|
gptkbp:resistantTo
|
efflux pumps
ribosomal protection proteins
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
photosensitivity
gastrointestinal upset
tooth discoloration
|
|
gptkbp:spectrumOfActivity
|
broad-spectrum
|
|
gptkbp:target
|
gptkb:30S_ribosomal_subunit
|
|
gptkbp:usedFor
|
gptkb:Rocky_Mountain_spotted_fever
Lyme disease
cholera
acne
sexually transmitted infections
urinary tract infections
bacterial infections
respiratory tract infections
malaria prophylaxis
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Antibiotics
|
|
gptkbp:bfsLayer
|
4
|