|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
hCE-1
CES1A1
liver carboxylesterase
|
|
gptkbp:associatedWith
|
obesity
hyperlipidemia
drug toxicity
nonalcoholic fatty liver disease
|
|
gptkbp:EC_number
|
3.1.1.1
|
|
gptkbp:encodedBy
|
CES1 gene
|
|
gptkbp:expressedIn
|
liver
macrophages
monocytes
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
detoxification
drug metabolism
hydrolyzes ester and amide bonds
|
|
gptkbp:gene
|
gptkb:CES1
|
|
gptkbp:HGNC_ID
|
gptkb:CES1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
carboxylesterase 1
|
|
gptkbp:inhibitedBy
|
gptkb:loperamide
benzil
|
|
gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:locatedOnChromosome
|
16q13-q22.1
|
|
gptkbp:molecularWeight
|
62 kDa
|
|
gptkbp:OMIM
|
114835
|
|
gptkbp:orthologInMouse
|
Ces1
|
|
gptkbp:PDB
|
1MX1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:proteinFamily
|
gptkb:carboxylesterase_family
|
|
gptkbp:RefSeq
|
NM_001025195
|
|
gptkbp:subcellularLocation
|
cytosol
microsome
|
|
gptkbp:substrate
|
gptkb:broadcaster
gptkb:irinotecan
gptkb:oseltamivir
gptkb:methylphenidate
cocaine
amphetamine
|
|
gptkbp:tissue_specificity
|
high in liver
low in brain
low in intestine
low in kidney
low in lung
|
|
gptkbp:UniProtID
|
P23141
|
|
gptkbp:bfsParent
|
gptkb:tenofovir_alafenamide
|
|
gptkbp:bfsLayer
|
7
|