Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:drug
|
| gptkbp:bfsLayer |
4
|
| gptkbp:bfsParent |
gptkb:tenofovir
|
| gptkbp:activities |
nucleotide reverse transcriptase inhibitor
|
| gptkbp:appointed_by |
oral tablet
|
| gptkbp:approves |
gptkb:2015
gptkb:FDA |
| gptkbp:brand |
gptkb:Descovy
|
| gptkbp:clinical_trial |
Phase 3
approximately 100% when taken with food in combination with other antiretrovirals |
| gptkbp:contraindication |
renal impairment
hypersensitivity to tenofovir |
| gptkbp:developed_by |
gptkb:Gilead_Sciences
|
| gptkbp:education |
importance of adherence to therapy
need for regular medical follow-up potential side effects to monitor for |
| gptkbp:financial_performance |
stable at room temperature
|
| gptkbp:formulation |
fixed-dose combination
|
| https://www.w3.org/2000/01/rdf-schema#label |
tenofovir alafenamide
|
| gptkbp:indication |
pre-exposure prophylaxis (Pr EP) for HIV
|
| gptkbp:ingredients |
C21 H29 N5 O10 P
|
| gptkbp:interacts_with |
nephrotoxic drugs
other antiviral medications |
| gptkbp:is_available_on |
generic version
|
| gptkbp:is_monitored_by |
renal function recommended during treatment
|
| gptkbp:is_used_for |
treatment of HIV
treatment of hepatitis B |
| gptkbp:lifespan |
approximately 12 hours
|
| gptkbp:marketed_as |
gptkb:legislation
gptkb:Australia gptkb:United_States gptkb:Native_American_tribe |
| gptkbp:pharmacokinetics |
gptkb:tenofovir
improved compared to tenofovir disoproxil fumarate inhibits HIV reverse transcriptase |
| gptkbp:provides_information_on |
recommended for hepatitis B treatment in certain populations
recommended for HIV treatment in certain populations |
| gptkbp:related_to |
gptkb:tenofovir_disoproxil_fumarate
|
| gptkbp:research_focus |
HIV prevention strategies
long-acting formulations |
| gptkbp:rounds |
urine
|
| gptkbp:safety_features |
generally well tolerated
|
| gptkbp:side_effect |
fatigue
headache nausea abdominal pain diarrhea lactic acidosis hepatotoxicity lipid abnormalities bone mineral density loss |
| gptkbp:storage |
store in a cool, dry place
|
| gptkbp:type_of |
150107-68-0
|
| gptkbp:type_of_care |
important for treatment efficacy
|