cAMP-dependent protein kinase (PKA)

URI: https://gptkb.org/entity/cAMP-dependent_protein_kinase_(PKA)
GPTKB entity
Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activatedBy cyclic AMP
gptkbp:alsoKnownAs gptkb:protein_kinase_A
gptkbp:composedOf catalytic subunits
regulatory subunits
gptkbp:discoveredBy gptkb:Earl_Sutherland
gptkbp:EC_number 2.7.11.11
gptkbp:foundIn eukaryotes
gptkbp:function phosphorylation of serine/threonine residues
gptkbp:gene gptkb:PRKACA
gptkb:PRKACB
gptkb:PRKACG
gptkb:PRKAR1B
gptkb:PRKAR2A
gptkb:PRKAR2B
gptkb:PRKAR1A
https://www.w3.org/2000/01/rdf-schema#label cAMP-dependent protein kinase (PKA)
gptkbp:inhibitedBy H-89
KT5720
protein kinase inhibitor peptide (PKI)
gptkbp:involvedIn gptkb:cAMP_signaling_pathway
apoptosis
cell proliferation
signal transduction
immune response
learning and memory
regulation of transcription
regulation of lipid metabolism
cardiac contractility
regulation of glycogen metabolism
regulation of ion channels
gptkbp:locale gptkb:nucleus
gptkb:cytoplasm
mitochondria
gptkbp:OMIM 188830
gptkbp:PDB 1ATP
gptkbp:phosphorylates gptkb:AMP-activated_protein_kinase
gptkb:CREB
gptkb:hormone-sensitive_lipase
gptkb:phospholamban
gptkb:phosphofructokinase-2
L-type calcium channel
glycogen synthase kinase
gptkbp:regulates gene expression
metabolism
cell growth
memory formation
gptkbp:structure tetramer
gptkbp:subunit C (catalytic)
R (regulatory)
gptkbp:UniProtID P17612
gptkbp:bfsParent gptkb:ATP-binding_cassette_sub-family_C_member_7
gptkbp:bfsLayer 7