Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:affects |
cholesterol levels
|
| gptkbp:aminoAcidChange |
arginine at positions 112 and 158
|
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
gptkb:cardiovascular_disease |
| gptkbp:discoveredBy |
gptkb:Allen_Roses
|
| gptkbp:frequency |
~14% worldwide
|
| https://www.w3.org/2000/01/rdf-schema#label |
APOE ε4
|
| gptkbp:impact |
lipid metabolism
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_19
|
| gptkbp:riskFactor |
gptkb:Alzheimer's_disease
gptkb:late-onset_Alzheimer's_disease cognitive decline atherosclerosis cerebral amyloid angiopathy sleep disturbances Lewy body dementia increased risk of herpes simplex virus encephalitis Parkinson's disease progression age-related cognitive impairment earlier onset of Alzheimer's disease increased amyloid-beta deposition increased risk of Creutzfeldt-Jakob disease increased risk of Down syndrome dementia increased risk of Huntington's disease progression increased risk of age-related macular degeneration increased risk of amyotrophic lateral sclerosis increased risk of autism spectrum disorder increased risk of bipolar disorder increased risk of delirium increased risk of depression increased risk of epilepsy increased risk of frontotemporal dementia increased risk of glaucoma increased risk of mild cognitive impairment increased risk of post-traumatic stress disorder increased risk of schizophrenia increased risk of severe COVID-19 increased risk of vascular dementia multiple sclerosis progression poor outcome after stroke poor outcome after traumatic brain injury poorer cognitive recovery after COVID-19 poorer cognitive recovery after anesthesia poorer cognitive recovery after chemotherapy poorer cognitive recovery after surgery reduced brain glucose metabolism reduced hippocampal volume reduced response to statins |
| gptkbp:variant |
gptkb:APOE
|
| gptkbp:bfsParent |
gptkb:阿茲海默症
gptkb:APOE_gene gptkb:apolipoprotein_E |
| gptkbp:bfsLayer |
6
|