|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
ApoB
Apolipoprotein B-100
Apolipoprotein B-48
|
|
gptkbp:associatedWith
|
gptkb:familial_hypercholesterolemia
atherosclerosis
|
|
gptkbp:binds
|
gptkb:LDL_receptor
|
|
gptkbp:component
|
gptkb:IDL
gptkb:chylomicrons
gptkb:VLDL
gptkb:LDL
|
|
gptkbp:degradedBy
|
liver
|
|
gptkbp:domain
|
lipid-binding domain
receptor-binding domain
|
|
gptkbp:encodedBy
|
gptkb:APOB_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:APOB
338
|
|
gptkbp:expressedIn
|
gptkb:hepatocytes
enterocytes
intestine (apoB-48)
liver (apoB-100)
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:foundIn
|
humans
other mammals
|
|
gptkbp:function
|
lipid transport
structural protein of lipoproteins
|
|
gptkbp:halfLife
|
2-3 days (apoB-100)
|
|
gptkbp:hasIsoform
|
gptkb:apolipoprotein_B-100
gptkb:apolipoprotein_B-48
|
|
gptkbp:HGNC_ID
|
603
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
apolipoprotein B
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
|
|
gptkbp:measures
|
blood tests
|
|
gptkbp:molecularWeight
|
~240 kDa (apoB-48)
~550 kDa (apoB-100)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:abetalipoproteinemia
familial hypobetalipoproteinemia
|
|
gptkbp:OMIM
|
107730
|
|
gptkbp:PDB
|
6VYO
|
|
gptkbp:presentIn
|
gptkb:plasma
|
|
gptkbp:referenceGenome
|
gptkb:NP_000375.2
|
|
gptkbp:requires
|
assembly of lipoprotein particles
|
|
gptkbp:role
|
cholesterol metabolism
triglyceride transport
|
|
gptkbp:significance
|
marker for cardiovascular risk
|
|
gptkbp:structure
|
single polypeptide chain
|
|
gptkbp:target
|
gptkb:PCSK9_inhibitors
statins
|
|
gptkbp:UniProtID
|
gptkb:P04114
|
|
gptkbp:bfsParent
|
gptkb:APOB_gene
|
|
gptkbp:bfsLayer
|
7
|