Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:pharmaceuticals
|
| gptkbp:administered_by |
injection
|
| gptkbp:approves |
gptkb:2015
gptkb:FDA |
| gptkbp:associated_with |
reduced stroke risk
improved cardiovascular outcomes reduced heart attack risk |
| gptkbp:available_in |
gptkb:various_countries
|
| gptkbp:clinical_trial |
ongoing studies
Phase III trials Phase IV trials |
| gptkbp:clinical_use |
adjunct to diet
adjunct to statin therapy primary prevention of cardiovascular events secondary prevention of cardiovascular events |
| gptkbp:contraindication |
hypersensitivity to the drug
|
| gptkbp:developed_by |
gptkb:Sanofi
gptkb:Amgen |
| gptkbp:example |
gptkb:Alirocumab
gptkb:Evolocumab |
| gptkbp:formulation |
monoclonal antibodies
|
| gptkbp:funding |
academic institutions
government grants pharmaceutical companies |
| https://www.w3.org/2000/01/rdf-schema#label |
PCSK9 inhibitors
|
| gptkbp:influences |
cholesterol metabolism
LDL receptor levels |
| gptkbp:interacts_with |
gptkb:ezetimibe
statins other lipid-lowering therapies |
| gptkbp:invention |
patented
|
| gptkbp:marketed_as |
gptkb:Repatha
gptkb:Praluent |
| gptkbp:mechanism_of_action |
inhibit PCSK9 protein
|
| gptkbp:patient_population |
adults with high cholesterol
patients with atherosclerotic cardiovascular disease children with high cholesterol patients with diabetes and high cholesterol patients with metabolic syndrome |
| gptkbp:price |
high
|
| gptkbp:provides_guidance_on |
included in cholesterol management guidelines
|
| gptkbp:regulatory_compliance |
approved for use in adults
approved for use in children with familial hypercholesterolemia |
| gptkbp:research_focus |
cost-effectiveness
long-term safety cardiovascular risk reduction |
| gptkbp:research_output |
enhanced quality of life
improved patient adherence reduced LDL levels |
| gptkbp:side_effect |
muscle pain
injection site reactions flu-like symptoms |
| gptkbp:target_audience |
patients with cardiovascular disease
patients with familial hypercholesterolemia patients with hyperlipidemia |
| gptkbp:used_for |
lowering LDL cholesterol
|
| gptkbp:bfsParent |
gptkb:FOURIER_trial
gptkb:familial_hypercholesterolemia |
| gptkbp:bfsLayer |
6
|