Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:ITGA4
CD49d |
| gptkbp:binds |
gptkb:fibronectin
gptkb:MAdCAM-1 gptkb:VCAM-1 |
| gptkbp:component |
integrin alpha-4 beta-1
integrin alpha-4 beta-7 |
| gptkbp:discoveredIn |
late 1980s
|
| gptkbp:encodedBy |
gptkb:ITGA4_gene
|
| gptkbp:expressedIn |
gptkb:leukocytes
|
| gptkbp:formsComplexWith |
gptkb:integrin_beta-1
gptkb:integrin_beta-7 |
| gptkbp:foundIn |
humans
other mammals |
| gptkbp:function |
cell adhesion
leukocyte migration |
| https://www.w3.org/2000/01/rdf-schema#label |
alpha-4 integrin
|
| gptkbp:locatedOnChromosome |
2q31-q32
|
| gptkbp:molecularWeight |
150 kDa
|
| gptkbp:role |
gptkb:Crohn's_disease
multiple sclerosis inflammatory bowel disease |
| gptkbp:structure |
transmembrane glycoprotein
|
| gptkbp:target |
gptkb:vedolizumab
gptkb:natalizumab |
| gptkbp:bfsParent |
gptkb:natalizumab
|
| gptkbp:bfsLayer |
7
|