|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:ADK
Ado kinase
|
|
gptkbp:associatedWith
|
gptkb:cancer
inflammation
epilepsy (when mutated or dysregulated)
|
|
gptkbp:catalyzes
|
phosphorylation of adenosine to AMP
|
|
gptkbp:EC_number
|
2.7.1.20
|
|
gptkbp:Ensembl_ID_(human)
|
ENSG00000156110
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
|
|
gptkbp:firstDescribed
|
1950s
|
|
gptkbp:foundIn
|
gptkb:Bacteria
humans
mammals
plants
|
|
gptkbp:gene
|
gptkb:ADK
|
|
gptkbp:gene_ID_(human)
|
132
|
|
gptkbp:HGNC_ID
|
HGNC:260
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
adenosine kinase
|
|
gptkbp:importantFor
|
energy homeostasis
modulation of neurotransmission
regulation of extracellular adenosine
|
|
gptkbp:inhibitedBy
|
5-iodotubercidin
ABT-702
increased adenosine levels
|
|
gptkbp:involves
|
purine metabolism
adenosine metabolism
|
|
gptkbp:locatedOnChromosome
|
10q11.23
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~40 kDa
|
|
gptkbp:OMIM
|
103050
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
gptkb:yeast
gptkb:Arabidopsis_thaliana
right
|
|
gptkbp:PDB
|
1BX4
|
|
gptkbp:product
|
gptkb:AMP
gptkb:ADP
|
|
gptkbp:RefSeq_(human)
|
NM_001123
|
|
gptkbp:regulates
|
intracellular adenosine levels
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:ATP
gptkb:adenosine
|
|
gptkbp:UniProtID
|
gptkb:Q9UKG1
|
|
gptkbp:bfsParent
|
gptkb:CHEBI:36208
|
|
gptkbp:bfsLayer
|
6
|